Wx Infinity Forums

jasons2k wrote: ↑Thu May 14, 2020 10:41 pm https://www.foreignaffairs.com/articles ... -be-worlds

unome wrote: ↑Thu May 21, 2020 6:49 pm https://www.houstonchronicle.com/news/h ... 286096.php

Using cellphone data, national study predicts huge June spike in Houston coronavirus cases

Ptarmigan wrote: ↑Thu May 21, 2020 9:50 pm Simulated Sunlight Rapidly Inactivates SARS-CoV-2 on Surfaces
https://academic.oup.com/jid/advance-ar ... 74/5841129

Sunlight does sterilize and destroy COVID-19 virus.

Our epidemiological analysis of the Covid-19 pandemic clearly indicates a decrease of prevalence and impact of SARS-CoV-2 infection in populations living at altitude of above 3,000 masl. The reason for decreased severity of the global COVID-19 outbreak at high altitude could relate to both environmental and physiological factors.

Environmental factors may influence the virulence of SARS-CoV-2 at high-altitude. Indeed, a high-altitude environment is characterized by drastic changes in temperature between night and day, air dryness, and high levels of ultraviolet (UV) light radiation (United-States-Environmental-Protection-Agency 2017). In particular UV light radiation A (UVA) and B (UVB) is well known to be capable of producing alterations in the molecular bonds of the DNA and RNA, and thus UV radiation at high-altitude may act as a natural sanitizer (Andrade 2020; Zubieta-Calleja 2020a; Zubieta-Calleja and Zubieta-DeUrioste 2017). In relation to SARS-CoV-2, while complete disinfection cannot be achieved by UVA and UVB, these radiations should shorten the half-life of any given virus (Andrade 2020; Zubieta-Calleja 2020b). It is clear that, all together, these factors may dramatically reduce the “survival” capacity of the virus at high-altitude, and therefore its virulence. Finally, due to the lower density of air and greater distance between molecules at high-altitude, the size of the airborne virus inoculum must be smaller than at sea level.

Although the data of the present study suggest a strongly decreased pathogenicity of SARS-CoV-2 in high-altitude, there is yet no evidence of an underlying physiological mechanisms that could affect to severity of infection. However, there is a positive correlation between the infection rate of SARS-CoV-1 and ACE2 in pulmonary epithelial cells. Importantly both SARS-CoV-1 and SARS-CoV-2 bind to ACE2 (Lu et al. 2020; Rothan and Byrareddy 2020; van Doremalen et al., 2020), and thus a putative decrease of ACE2 expression in pulmonary endothelia in high-altitude inhabitant could represent a physiological protective for the severe and often lethal pulmonary edema.

Ptarmigan wrote: ↑Tue Jun 02, 2020 9:51 pm Does the pathogenesis of SAR-CoV-2 virus decrease at high-altitude?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175867/

Our epidemiological analysis of the Covid-19 pandemic clearly indicates a decrease of prevalence and impact of SARS-CoV-2 infection in populations living at altitude of above 3,000 masl. The reason for decreased severity of the global COVID-19 outbreak at high altitude could relate to both environmental and physiological factors.

Environmental factors may influence the virulence of SARS-CoV-2 at high-altitude. Indeed, a high-altitude environment is characterized by drastic changes in temperature between night and day, air dryness, and high levels of ultraviolet (UV) light radiation (United-States-Environmental-Protection-Agency 2017). In particular UV light radiation A (UVA) and B (UVB) is well known to be capable of producing alterations in the molecular bonds of the DNA and RNA, and thus UV radiation at high-altitude may act as a natural sanitizer (Andrade 2020; Zubieta-Calleja 2020a; Zubieta-Calleja and Zubieta-DeUrioste 2017). In relation to SARS-CoV-2, while complete disinfection cannot be achieved by UVA and UVB, these radiations should shorten the half-life of any given virus (Andrade 2020; Zubieta-Calleja 2020b). It is clear that, all together, these factors may dramatically reduce the “survival” capacity of the virus at high-altitude, and therefore its virulence. Finally, due to the lower density of air and greater distance between molecules at high-altitude, the size of the airborne virus inoculum must be smaller than at sea level.

Although the data of the present study suggest a strongly decreased pathogenicity of SARS-CoV-2 in high-altitude, there is yet no evidence of an underlying physiological mechanisms that could affect to severity of infection. However, there is a positive correlation between the infection rate of SARS-CoV-1 and ACE2 in pulmonary epithelial cells. Importantly both SARS-CoV-1 and SARS-CoV-2 bind to ACE2 (Lu et al. 2020; Rothan and Byrareddy 2020; van Doremalen et al., 2020), and thus a putative decrease of ACE2 expression in pulmonary endothelia in high-altitude inhabitant could represent a physiological protective for the severe and often lethal pulmonary edema.

jasons2k wrote: ↑Wed Feb 03, 2021 3:08 pm Another article about the weather’s influence on the virus:

https://www.studyfinds.org/weather-impa ... 19-spread/